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| Product Name | PBRM1, Bromodomain 1, Recombinant, Human, aa23-156, GST-tag |
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| Description | Purity ~95% (SDS-PAGE). The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as ``readers'' of histone acetylation marks regulating the transcription of target promoters. The PBRM1 gene encodes the bromodomain-containing protein Polybromo-1D (PBRM1). PBRM1 contains six bromodomains and is a component of the SWI/SNF complex, PBAF. PBAF is targeted to acetylated sites in chromatin by the PBRM1 bromodomains, where it plays a role in cell cycle regulation and tumor suppression. This product contains the bromodomain 1 region of PBRM1. Sour |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PBRM1, Bromodomain 1, Recombinant, Human, aa23-156, GST-tag (Polybromo 1D, MGC165155, MGC165156, BAF180, Protein Polybromo-1, BRG1-associated Factor 180, hPB1, PB1) |
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| Gene, Accession, CAS # | PBRM1, Gene ID: 55193, SwissProt: Q86U86 |
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| Catalog # | 220131 |
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| Order / More Info | PBRM1, Bromodomain 1, Recombinant, Human, aa23-156, GST-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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