| 产品详情 |
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| Product Name | Hhat Inhibitor, RU-SKI 43 |
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| Description | Purity ~98% (HPLC). A cell-permeable dihydrothienopyridinyl-ethanone compound that acts as an effective inhibitor against MBOAT family member Hhat/hedgehog acyltransferase-catalyzed ShhN palmitoylation in a palmitoyl CoA-noncompetitive (Ki = 6,9uM; [ShhN] = 38uM) and ShhN-uncompetitive (Ki = 7.4uM; [palmitoyCoA] = 30uM) manner. Effectively prevents Shh- & Hhat-transfected COS-1 cells from activating hedgehog signaling in co-cultured C3H10T1/2 cells (~80% inhibition with10uM inhibitor) by inhibiting COS-1 intracellular ShhN palmitoylation (by 52% and 80%, respectively, with 10 or 20uM drug treatment) without affecting cellular palmitoylation of H-ras & fyn, myristoylation of c-Src & Wnt3a, Shh autoprosessing, or the protein level and localization of Shh & Hhat. Exhibits short plasma half-life in mice (t1/2 = 17 min; i.v.). Primary Target: Hhat Solubility: DMSO |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Hhat Inhibitor, RU-SKI 43 (2-(2-Methylbutylamino)-1-(4-(m-tolyloxymethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone, 2-((2-Methylbutyl)amino)-1-(4-((3-methylphenoxy)methyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone, Hedgehog Acyltransferase Inhibitor, RU-SKI43) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217423 |
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| Order / More Info | Hhat Inhibitor, RU-SKI 43 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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