| 产品详情 |
| Edit |   |
|---|
| Product Name | PrCP Inhibitor |
|---|
| Description | Purity ~97% (HPLC). A dichlorobenzimidazolopyrrolidinamide compound that acts as a highly potent PrCP-selective inhibitor (IC50 = 1nM against human PrCP; IC50 = 2 and 8nM against mouse PrCP, respectively, in the absence or presence of 1% mouse serum albumin), presumably via non-covalent catalytic site interaction, while exhibiting no significant potency toward panels of ion channels, receptors, and enzymes, including homologous serine proteases QPP, FAP, PEP, ACE2, DPP4, DPP8, and DPP9 (IC50 >25uM). Oral administration (100mg/kg/d for 5 d) is reported to result in significant food intake reduction and body fat loss among high fat diet-induced obese mice in vivo. Solubility: DMSO (100mg/ml) Proton NMR Spectroscopic: Conforms to structure Liquid Chromatography Mass Spectrometry: Conforms to structure Elemental Analysis: Calculated: %C: 57-65; %H: 5-7 ; %N: 10.5-12.5 Water (CHN): ≥0mol |
|---|
| Size | 10mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | PrCP Inhibitor (Angiotensinase C Inhibitor, Lysosomal Carboxypeptidase C Inhibitor, Lysosomal Pro-X Carboxypeptidase Inhibitor, PCP Inhibitor, Proline Carboxypeptidase Inhibitor, Prolylcarboxypeptidase Inhibitor, 2-Amino-N-((2S,3S)-3-(biphenyl-4-yl)-1-((2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)-2-methylpropanamide) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 217695 |
|---|
| Price | |
|---|
| Order / More Info | PrCP Inhibitor from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|