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| Product Name | Matrix Metalloproteinase 17 MT4, Recombinant Catalytic Domain (MT4-MMP-17) |
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| Description | MT4-MMP catalytic domain appears as a homogeneous band at 24kD in SDS-PAGE. Matrix metalloproteinases (MMPs) are Zn2+- and Ca2+-dependent endopeptidases which function in the turnover of extracellular matrix components (1). Presently, eighteen secreted MMPs and five membrane- type MMPs (2-5) are known to be expressed in vertebrates. Human MT4-MMP consists of 478aa with a calculated Mr of 53,428D. The following domains and sequence regions are distinguished in MT4-MMP: Prodomain, catalytic domain junction between catalytic domain and hemopexin domain, hemopexin-like domain and C-terminal sequence with transmembrane segment. MT4-MMP transcripts are found mainly in brain, leukocytes, colon, ovary and testis (5). In addition, MT4-MMP mRNA is transcribed in invasive and noninvasive breast carcinoma cell lines (5,6). The recombinant catalytic domain of MT4-MMP is useful for the study of tumorigenesis, arthritis, and inflammatory processes. The enzyme allows screening of matrix metallo- prote |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | M2432-05 |
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| Order / More Info | Matrix Metalloproteinase 17 MT4, Recombinant Catalytic Domain (MT4-MMP-17) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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