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| Product Name | Matrix Metalloproteinase, Pro, 13, Recombinant (ProMMP-13, Procollagenase III) |
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| Description | Pro-MMP-13 appears as a major band at about 60kD in SDS-PAGE (> 95% total protein). Matrix metalloproteinases (MMPs) are Zn 2+-and Ca 2+-dependent endopeptidases which function in the turnover of extracellular matrix components (1). Main subfamilies of MMP are collagenases, gelatinases, stromelysins and membrane-type matrix metalloproteinases (2). Three homologous collagenases have been identified in human tissues: Interstitial collagenase, neutrophil collagenase and collagenase-3. These three enzymes cleave fibrillar collagens at a single site, generating fragments of approximately 3/4 and 1/4 the size of the original molecules. ProMMP-13 (Procollagenase-3) consists of 452 amino acids with a calculated Mr of 52.520(3). Due to N-linked glycosylation, the actual Mr is about 60000 Da (4). Within the protein the following domains and sequence regions can be distinguished (3,4): An N-terminal propeptide, which confers latency to the proenzyme, a Ca2+ and Zn2+-ion binding catalytic domain, |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_002427.2, SwissProt: P45452 |
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| Catalog # | M2428-13 |
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| Order / More Info | Matrix Metalloproteinase, Pro, 13, Recombinant (ProMMP-13, Procollagenase III) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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