| 产品详情 |
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| Product Name | Matrix Metalloproteinase 13, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). MMP-13 (Collagenase-3) was first identified in human mammacarcinoma (Freije et al., 1994, Willmroth et al. 1998)-probably induced by IL1- alpha and IL-1 beta - and shown to be glycosylated and the inactive zymogen displaying a relative molecular weight of 60kD. Cleavage of the 84 residue propeptide can be catalysed by other MMPs such as MMP-2, MMP-3 and MMP-14, or by factors like plasmin. The proenzyme activated by APMA (paminohenylmercuric acteate) or leads to the active enzyme with a relative molecular weight of app. 48kD which easily autodegrades into a 30kD form. This highly active 30kD form still retains the characteristics of the app. 48kD form. MMP-13 also plays a central role in the MMP activation cascade, both activating and being activated by several MMPs (Leeman et al., 2002). This product contains neither an N- nor C-terminal tag. This product is APMA activated, which had been removed after activation employing SEC and dialysis. Source: Recombinant c |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Matrix Metalloproteinase 13, Recombinant, Human (Matrix Metalloproteinase-13, MMP13, MMP-13, Collagenase 3) |
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| Gene, Accession, CAS # | SwissProt: P45452 |
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| Catalog # | M2428-27F |
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| Order / More Info | Matrix Metalloproteinase 13, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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