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| Product Name | Matrix Metalloproteinase 9, Recombinant, Human (MMP-9, Collagenase 4, Gelatinase B) |
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| Description | Purity ~95% by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin: ≤ 0.1EU/ug. EC 3.4.24.35 Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-9 (gelatinase B) can degrade a broad range of substrates including gelatin, collagen types IV and V, elastin and proteoglycan core protein. It is believed to act synergistically with interstitial collagenase (MMP-1) in the degradation of fibrillar collagens as it degrades their denatured gelatin forms. MMP-9 is produced by keratinocytes, monocytes, macrophages and PMN leukocytes. MMP-9 is present in most cases of inflammatory responses. Structurally, MMP-9 maybe be divided into five distinct domains: a pro-domain which is cleaved upon activation, a gelatin-binding domain consisting of three contiguous fibronectin type II units, a catalytic domain containing the zinc binding site, a proline-rich linke |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 4318, SwissProt: P14780 |
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| Catalog # | M2425-22B |
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| Order / More Info | Matrix Metalloproteinase 9, Recombinant, Human (MMP-9, Collagenase 4, Gelatinase B) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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