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| Product Name | Matrix Metalloproteinase 7, Recombinant, Human (MMP7, Matrilysin, PUMP) |
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| Description | Purity ~95% (RP-HPLC, SDS-PAGE). Matrix metalloproteinase-7 (MMP-7), also known as matrilysin and PUMP (EC 3.4.24.23), cleaves a number of substrates including collagen types IV and X, elastin, fibronectin, gelatin, laminin and proteoglycans. MMP-7 is closely related to the stromelysin family members but is encoded by a different gene. MMP-7 is the smallest of all the MMPs consisting of a pro-peptide domain and a catalytic domain. It lacks the hemopexin-like domain common to other members of the MMPs. MMP-7 is secreted as a 28kD proenzyme and can be activated in vitro by organomercurials and trypsin and in vivo by MMP-3 to a 18kD active MMP-7 enzyme. Once activated, MMP-7 can activate pro-MMP-1 and pro-MMP-9 but not pro-MMP-2. MMP-7 is widely expressed having been reported in elevated levels in cycling endometrium as well as in colorectal cancers and adenomas, hepatocellular carcinomas, rectal carcinomas, and approximately 50% of gliomas. Source: Recombinant protein corresponding to hu |
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| Size | 5ug, 20ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 299450 |
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| Order / More Info | Matrix Metalloproteinase 7, Recombinant, Human (MMP7, Matrilysin, PUMP) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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