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| Product Name | CREB3L2, Recombinant, Human, aa1-247, GST-Tag (Cyclic AMP-responsive Element-binding Protein 3-like Protein 2) |
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| Description | Purity ~90% (SDS-PAGE). Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes. In a neuroblastoma cell line, protects cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site. Source: Recombinant protein corresponding to aa1-247 from human CREB3L2, fused to GST-Tag at N-termin |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | BBF2 human homolog on chromosome 7 |
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| Gene, Accession, CAS # | SwissProt: Q70SY1 |
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| Catalog # | 372863 |
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| Order / More Info | CREB3L2, Recombinant, Human, aa1-247, GST-Tag (Cyclic AMP-responsive Element-binding Protein 3-like Protein 2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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