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| Product Name | PRKAG2, Recombinant, Human, aa1-328, His-Tag (5'-AMP-activated Protein Kinase Subunit gamma-2) |
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| Description | Purity ~90% (SDS-PAGE). AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating alread |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | H91620p |
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| Gene, Accession, CAS # | SwissProt: Q9UGJ0 |
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| Catalog # | 374850 |
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| Order / More Info | PRKAG2, Recombinant, Human, aa1-328, His-Tag (5'-AMP-activated Protein Kinase Subunit gamma-2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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