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| Product Name | USP14, Recombinant, Human, aa1-494, His-Tag (Ubiquitin C-terminal Hydrolase 14) |
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| Description | Purity ~90% (SDS-PAGE). Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Source: Recombinant protein corresponding to aa1-494 from human USP14, fused to His-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~60.1kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Deubiquitinating enzyme 14, Ubiquitin thioesterase 14, Ubiquitin-specific-processing protease 14 |
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| Gene, Accession, CAS # | SwissProt: P54578 |
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| Catalog # | 375796 |
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| Order / More Info | USP14, Recombinant, Human, aa1-494, His-Tag (Ubiquitin C-terminal Hydrolase 14) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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