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| Product Name | USP25, Recombinant, Human, His-Tag (Ubiquitin Thiolesterase 25, USP21) |
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| Description | Purity ~90% (SDS-PAGE). USP25 (Ubiquitin Specific Protease 25) is a deubiquitinating enzyme of the C19 family that is expressed in many human tissue types. USP25 activity is modulated by a sumoylation event that is dependent on the presence of a SUMO-interaction domain (SIM) located in the amino-terminal region of all USP25 isoforms. Sumoylation occurs within one of two ubiquitin interaction motifs (UIMs) that are required for efficient in vitro hydrolysis of polyubiquitin chains (K48-linked or K63-linked) by USP25. While sumoylation impairs USP25 activity again polyubiquitin substrates, it does not affect its hydrolysis of ubiquitin-AMC. This protein contains a C-terminal 6-His tag. Source: Recombinant protein corresponding to human USP25, fused to 6-his tag at C-terminal. Molecular Weight: ~123kD |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q9UHP3 |
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| Catalog # | 145857 |
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| Order / More Info | USP25, Recombinant, Human, His-Tag (Ubiquitin Thiolesterase 25, USP21) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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