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| Product Name | M-CSF, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). M-CSF is produced by monocytes, granulocytes, endothelial cells, and fibroblasts. After cell activation, B cells and T cells and also a number of tumor cell lines are capable also of synthesizing this factor. M-CSF has been found to be synthesized by uterine epithelial cells in vivo. The M-CSF receptor is identical with the proto-oncogene fms. It has been renamed CD115. The receptor is a transmembrane protein with an extracellular ligand-binding domain of 512aa, an intramembrane domain of 25aa, and a cytoplasmic domain of 435aa encoding a tyrosine kinase. Human M-CSF is active in mouse and rat cells. The murine factor is active in rat cells but inactive in human cells. M-CSF is a specific factor in that the proliferation inducing activity is more or less restricted to the macrophage lineage. M-CSF is a potent stimulator of functional activities of monocytes. Recombinant Human M-CSF is expressed in human 293 cells and has an apparent molecular mass of 35-40kD due to glycosylation. Sourc |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | M-CSF, Recombinant, Human (Macrophage Colony-Stimulating Factor 1, CSF-1, M-CSF, MCSF, Lanimostim, Macrophage Colony Stimulating Factor, CSF1) |
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| Gene, Accession, CAS # | SwissProt: P09603 |
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| Catalog # | 500224 |
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| Order / More Info | M-CSF, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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