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| Product Name | CK2a1, Active, Recombinant, Human (Casein Kinase 2 alpha) |
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| Description | Purity ~90% (SDS-PAGE). CK2 alpha (also termed casein kinase II alpha) is a serine-threonine protein kinase whose targets include many critical regulators of cellular growth. It is highly expressed in a lympho pro-liferative disease of cattle and in many human cancers. Overexpression of the CK2 alpha catalytic subunit in lymphocytes of transgenic mice leads to T cell lymphoma (1). The highest CK2 activity is found in mouse testicles and brain, followed by spleen, liver, lung, kidney and heart (2). The activity values were directly correlated with the protein expression level of the CK2alpha (catalytic subunit). The alpha subunit is only detected in brain and testicles. By contrast, Northern blot analyses of the CK2 alpha mRNA shows the strongest signals to be present in brain, liver, heart and lung. In kidney, spleen and testicles mRNAs is only weakly detectable. ICBP90, a transcription factor exhibiting antiapoptotic property, has several putative CK2 phosphorylation sites. ICBP90 is |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Active CK2a1, CK2a1, CK2alpha1, CK2, human CK2a1, active kinase, active kinases, recombinant CK2a1, recombinant CK2, kinase activity assay, protein kinase |
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| Gene, Accession, CAS # | CK2A1, Gene ID: 1457, Accession: NM_001895 |
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| Catalog # | 219660 |
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| Order / More Info | CK2a1, Active, Recombinant, Human (Casein Kinase 2 alpha) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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