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| Product Name | IGF-II, Pro, Recombinant, Human (Insulin Like Growth Factor-II) |
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| Description | Purity ~95% (SDS-PAGE). The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Glycosylation contributes to stability in cell growth media and other applications. IGF-II expressed in E. coli is typically 7.5kD and nonglycosylated. This cytokine is produced in a human cell expression system with serum-free, chemica |
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| Size | 10ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P01344 |
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| Catalog # | 368994 |
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| Order / More Info | IGF-II, Pro, Recombinant, Human (Insulin Like Growth Factor-II) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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