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| Product Name | IL37, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). Member of the IL-1 family, IL-37 functions to curb excessive inflammation. In partnership with SMAD3, IL-37 suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Out of the five isoforms for IL-37 (a-e), this product represents isoform B that is expressed in testis, colon, placenta, lung and lymph node similar to isoform A and C but is the only one found in kidneys. Recombinant Human IL37/IL23 expressed in human 293 cells is a heterodimeric glycoprotein composed of two disulfide-linked subunits (p40 cystine linked to p19) with a molecular mass of 55kD. Source: Recombinant protein corresponding to human IL37 expressed in HEK293. Molecular Weight: ~55kD Biological Activity: The EC50 as determined by the dosedependent secretion of IL-17 in response to IL-23 using murine splenocytes was found to be ≤30ng/mL. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IL37, Recombinant, Human (IL-37, IL-23, FIL1 Zeta, IL-1X, Interleukin-1 Family Member 7, IL-1F7, IL1F7, Interleukin-1 Homolog 4, IL-1H, IL-1H4, Interleukin-1 Zeta, IL-1 Zeta, Interleukin-1-Related Protein, IL-1RP1, Interleukin-37/Interleukin-23) |
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| Gene, Accession, CAS # | SwissProt: Q9NZH6 |
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| Catalog # | 500161 |
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| Order / More Info | IL37, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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