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| Product Name | IL33, Recombinant, Human, aa112-270, His-Tag |
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| Description | Purity ~95%. Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1a/b, IL-1Ra and IL-18. Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein (IL-1RAcP). Receptor binding of IL-33 activates NF-kB and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also colocalize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. This recombinant protein represents the cleaved and presumably |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IL33, Recombinant, Human, aa112-270, His-Tag (Interleukin-33, IL-33, Interleukin-1 Family Member 11, IL-1F11, Nuclear Factor From High Endothelial Venules, NF-HEV, C9orf26, IL1F11, NFHEV) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 149774 |
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| Order / More Info | IL33, Recombinant, Human, aa112-270, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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