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| Product Name | Procathepsin K, Recombinant, Human (Cathepsin K, CTSK, CTSO, CTSO3) |
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| Description | Purity ~95% (SDS-PAGE). Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is synthesized as an inactive proenzyme (35.1kD) that is converted to its mature active form (23.6kD) by proteolytic cleavage of its 99aa propeptide domain. The in vitro processing of procathepsin K to mature cathepsin K is autocatalytic. Source: Recombinant protein corresponding to human Procathepsin K, expressed in E. coli. Molecular Weight: ~35.9kD Specific Activity: >1000mU/mg (1U=1umole/min/mg) as measured by Cathepsin K Activity Assay Kit. |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CTSK, CTSO, CTSO3 |
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| Gene, Accession, CAS # | CATK, Gene ID: 1513, SwissProt: P43235 |
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| Catalog # | 220188 |
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| Order / More Info | Procathepsin K, Recombinant, Human (Cathepsin K, CTSK, CTSO, CTSO3) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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