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| Product Name | Procathepsin S, Recombinant, Human, aa17-331, His-Tag (CTSS) |
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| Description | Purity ~90% (SDS-PAGE). Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is synthesized as inactive precursor of 331aa consisting of a 15aa signal peptide, a propeptide of 99aa, and a mature polypeptide of 217aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicate that cathepsin S generates amyloid beta-peptide from amyloidogenic fragments of amyloid precursor protein (APP) in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer's disease and Down Syndrome. Source: Recombinant protein corresponding to human Procathepsin S |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | CTSS, Gene ID: 1520, SwissProt: P25774 |
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| Catalog # | 301271 |
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| Order / More Info | Procathepsin S, Recombinant, Human, aa17-331, His-Tag (CTSS) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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