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| Product Name | SMARCC1, Recombinant, Human, aa449-669, His-SUMO-Tag (SWI/SNF Complex Subunit SMARCC1) |
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| Description | Purity ~90% (SDS-PAGE). Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is es |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | BRG1-associated factor 155, BAF155SWI/SNF complex 155kD subunit, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 |
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| Gene, Accession, CAS # | SwissProt: Q92922 |
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| Catalog # | 375337 |
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| Order / More Info | SMARCC1, Recombinant, Human, aa449-669, His-SUMO-Tag (SWI/SNF Complex Subunit SMARCC1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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