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| Product Name | KCND2, Recombinant, Human, aa406-630, His-Tag (Potassium Voltage-gated Channel Subfamily D Member 2) |
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| Description | Purity ~85% (SDS-PAGE). Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons. This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhytm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity. Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5. Mediates the transient outward curr |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Voltage-gated potassium channel subunit Kv4.2 |
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| Gene, Accession, CAS # | SwissProt: Q9NZV8 |
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| Catalog # | 373902 |
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| Order / More Info | KCND2, Recombinant, Human, aa406-630, His-Tag (Potassium Voltage-gated Channel Subfamily D Member 2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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