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| Product Name | WNT1, Recombinant, Human (Proto-Oncogene Int-1 Homolog, Wnt-1, Proto-Oncogene Wnt-1) |
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| Description | Purity ~95% (SDS-PAGE). Wnt-1 is a secreted protein that signals through the frizzled family of seven transmembrane receptors. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the up-regulation of over fifty genes. Stabilization and resulting accumulation of the intracellular signaling protein beta-catenin is an important aspect of Wnt-1 signaling. While known to play in role as a developmental protein, elevated levels of Wnt proteins have also been associated with tumorigenesis. Source: Recombinant protein corresponding to human WNT1 expressed in E. coli. Molecular Weight: ~38.5kD Biological Activity: Determined by its ability to enhance BMP-2 induced alkaline phosphatase production by murine ATDC5 cells. The expected ED50 for this effect is 1.5-2.5ng/ml in the presence of 200ng/ml of human BMP-2. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P04628 |
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| Catalog # | 500550 |
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| Order / More Info | WNT1, Recombinant, Human (Proto-Oncogene Int-1 Homolog, Wnt-1, Proto-Oncogene Wnt-1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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