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| Product Name | GSK-3b, Recombinant, Human (Gsk3beta, Glycogen Synthase Kinase-3 (GSK-3), Active GSK-3b) |
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| Description | Purity ~90% (SDS-PAGE). Glycogen synthase kinase-3 (GSK-3) is a serine/theronine kinase that was first characterized by its role in intermediary metabolism. In mammals, serine kinase is encoded by two related genes called GSK-3a (51kD) and GSK-3b (46kD). GSK-3 has been implicated in the regulation of the c-Jun/AP-1 transcription factor and other intracellular signaling pathways. Source: Recombinant protein corresponding to human GSK-3b, expressed in E. coli. Molecular Weight: ~53-56kD Biological Activity: Determined by an in vitro kinase assay using 100ng Tau as substrate and 1ug of the recombinant GSK-3b in a 20ul reaction containing 25mM Tris-HCl, pH 7.5, 5mM beta-glycerol phosphate, 12mM MgCl2, 2mM DTT, 0.1M Na3VO4, 200uM ATP. After 30 minutes incubation at 30°C, phosphorylation of Tau by the recombinant GSK-3b was determined by Western blot using a phospho-Tau antibody. |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | gsk3b,Glycogen synthase kinase-3 (GSK-3), Active GSK-3b |
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| Gene, Accession, CAS # | GSK3B, Gene ID: 2932, SwissProt: P49841 |
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| Catalog # | 219824 |
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| Order / More Info | GSK-3b, Recombinant, Human (Gsk3beta, Glycogen Synthase Kinase-3 (GSK-3), Active GSK-3b) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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