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| Product Name | GSK-3b, Recombinant, Human (gsk3b, Glycogen synthase kinase-3 (GSK-3), Active GSK-3b) |
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| Description | Purity ~90% (SDS-PAGE). Glycogen synthase kinase-3 (GSK-3) is a serine/theronine kinase that was first characterized by its role in intermediary metabolism. In mammals, serine kinase is encoded by two related genes called GSK-3a (51kD) and GSK-3b (46kD). GSK-3 has been implicated in the regulation of the c-Jun/AP-1 transcription factor and other intracellular signaling pathways. Source: Recombinant corresponding to human GSK-3b expressed in E.coli. Molecular Weight: ~53-56kD Biological Activity: Activity of GSK-3b was determined by an in vitro kinase assay using 100ng Tau as substrate and 1ug of the recombinant GSK-3b in a 20ul reaction containing 25mM Tris-HCl, pH 7.5, 5mM b-glycerol phosphate, 12mM MgCl2, 2mM DTT, 0.1M Na3VO4, and 200uM ATP. After 30mins incubation at 30°C, phosphorylation of Tau by the recombinant GSK-3b was determined by Western blot using a phospho-Tau antibody. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 167849 |
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| Order / More Info | GSK-3b, Recombinant, Human (gsk3b, Glycogen synthase kinase-3 (GSK-3), Active GSK-3b) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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