| 产品详情 |
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| Product Name | Adenovirus Proteinase Inhibitor, NSC 37249 |
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| Description | Purity ~90% (HPLC). A sulfonyldiphenylene-bis-dicyclohexylaminoacetamide compound that acts as a potent and selective inhibitor against adenovirus cysteine proteinase AVP by targeting simultaneously AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket (Ki = 150nM) and AVP-pVIc substrate-binding site (Ki = 400nM), blocking both AVP-pVIc active complex formation (IC50 = 140nM; [substrate] = 5uM & [pVIc] = 40uM) and catalytic activity (IC50 = 490nM; [substrate] = 5uM) without affecting trypsin or papain protease activity even at concentrations as high as 10uM. Solubility: 5% TFA in EtOH Primary Target: AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket Secondary Target: AVP-pVIc substrate-binding site |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Adenovirus Proteinase Inhibitor, NSC 37249 (2-(Dicyclohexylamino)-N-(4-(4-((2-(dicyclohexylamino)acetyl)amino)phenyl)sulfonylphenyl)acetamide, N,N?-(Sulfonyldi-4,1-phenylene)bis(2-(dicyclohexylamino)acetamide, AVP Inhibitor) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217160 |
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| Order / More Info | Adenovirus Proteinase Inhibitor, NSC 37249 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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