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| Product Name | ANGPTL5, Recombinant, Human, 6-His-Tag |
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| Description | Purity ~90% (SDS-PAGE). Angiopoietin-like 5 (ANGPTL5) is a secreted glycoprotein that is structurally related to the angiopoietins which contain an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (1-3). It shares 88% and 93% aa sequence identity with bovine and porcine ANGPTL5, and greater than 98% identity with chimpanzee, orangutan, and rhesus ANGPTL5. ANGPTL5 is expressed in adipose, bronchial, epididymal, and heart tissue (3, 4). Rare polymorphisms and loss of function mutations in human ANGPTL5 are associated with low circulating triglyceride levels and alterations in body mass index (4, 5). ANGPTL5, when used in combination with other growth factors such as SCF, Thrombopoietin, IGF-II, FGF acidic, Flt-3 Ligand, and IGFBP-2, enhances the expansion and engraftment of human and mouse hematopoietic stem cells (6-8). The coiled-coil domain of ANGPTL proteins is critical for this effect. However, the molecular mechanism of ANGPTL proteins in stem cell activity rem |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ANGPTL5, Recombinant, Human, 6-His-Tag (Angiopoietin-related Protein 5, Angiopoietin-like Protein 5, UNQ5795/PRO19600) |
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| Gene, Accession, CAS # | Accession: AAH49170 |
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| Catalog # | A2293-49C |
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| Order / More Info | ANGPTL5, Recombinant, Human, 6-His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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