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| Product Name | ANGPTL7, Recombinant, Mouse, 10-His-Tag |
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| Description | Purity ~95% (SDS-PAGE). Angiopoietin-like 7 (ANGPTL7), also known as Corneal-Derived Transcript 6 (CDT6), is a secreted, 45-50kD glycoprotein member of the angiopoietin-like family of molecules. Members of this protein family contain an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. Mature mouse ANGPTL7 is 316aa in length. It shares 88% and 98% aa sequence identity with human and rat ANGPTL7, respectively. The ANGPTL7 monomer forms homotetramers via its coiled coil domain. ANGPTL7 is expressed in the corneal stroma, trabecular meshwork, and sclera. Its production is up-regulated in trabecular meshwork cells by glucocorticoids and TGF-b and in cartilage by TNF-a. Expression is up-regulated under conditions of increased ocular pressure (IOP). Since IOP is a risk factor for glaucoma, ANGPTL7 may represent a defense mechanism to reduce pressure on the retina. It appears that IOP is a consequence of increased ECM deposition, a major component of which is fibronectin. |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ANGPTL7, Recombinant, Mouse, 10-His-Tag (Angiopoietin-related Protein 7, Angiopoietin-like Protein 7) |
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| Gene, Accession, CAS # | Accession: NP_001034643 |
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| Catalog # | A2293-52S |
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| Order / More Info | ANGPTL7, Recombinant, Mouse, 10-His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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