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| Product Name | ANGPT2, Recombinant, Human (Angiopoietin-2, ANG-2) |
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| Description | Purity ≥95% by SDS-PAGE gel and HPLC analyses. ANG-2 binds to the endothelial cell specific receptor Tie2, but, in contrast to ANG-1 does not induce tyrosine phosphorylation.Consequently, ANG-2 modulates ANG-1 activation of Tie2 and, depending on the physiological and biochemical environment, can act either as an agonist or antagonist of Tie2 induced angiogenesis.The signaling interactions of ANG-1, ANG-2 and Tie2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels.Mature human ANG-2 is a secreted protein containing 480aa residues.ANG-2 is composed of an alpha helix rich coiled coil N-terminal domain and fibrinogen like C-terminal domain.ANG-2 exists predominantly in the form of a disulfide-linked dimer.Recombinant human ANG-2 is a C-terminal histidine tagged glycoprotein which migrates with an apparent mol |
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| Size | 5ug, 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 143276 |
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| Order / More Info | ANGPT2, Recombinant, Human (Angiopoietin-2, ANG-2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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