| 产品详情 |
| Edit |   |
|---|
| Product Name | ANG-2, Recombinant, Human, His-Tag (ANGPT-2, Angiopoietin-2) |
|---|
| Description | Purity ~95% (SDS-PAGE). ANG-2 binds to the endothelial cell specific receptor Tie2, but, in contrast to ANG-1 does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie2 and, depending on the physiological and biochemical environment, can act either as a n agonist or antagonist of Tie2 induced angiogenesis. The signaling interactions of ANG-1, ANG-2 and Tie2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels. Mature human ANG-2 is a secreted protein containing 480aa residues. ANG-2 is composed of an alpha helix rich ``coiled coil'' N-terminal domain and fibrinogen like C-terminal domain. ANG-2 exists predominantly in the form of a disulfide-linked dimer. Recombinant human ANG-2 is a C-terminal histidine tagged glycoprotein which migrates with an apparent molecular mass of |
|---|
| Size | 10ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | ANGPT-2 |
|---|
| Gene, Accession, CAS # | ANGPT2, Gene ID: 285, Accession: O15123 |
|---|
| Catalog # | 219374 |
|---|
| Price | |
|---|
| Order / More Info | ANG-2, Recombinant, Human, His-Tag (ANGPT-2, Angiopoietin-2) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|