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| Product Name | IL10, Recombinant, Mouse (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF, Interleukin-10) |
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| Description | Purity ~95% (SDS-PAGE). IL10 is produced by mouse Th2 cells following their stimulation by lectins. The main source for B cell derived IL10 in mice are Ly1 B cells that express CD5 (Ly1) and CD11. In humans IL10 is produced by activated CD8(+) peripheral blood T cells, by T helper CD4(+) T cell clones after both antigen-specific and polyclonal activation, by B cell lymphomas, and by monocytes following cell activation by bacterial lipopolysaccharides and mast cells. IL10 is a homodimeric protein with subunits having a length of 160aa. Human IL10 shows 73% amino acid homology with mouse IL10. IL10 inhibits the synthesis of a number of cytokines such as IFN-gamma, IL-2 and TNF-beta in Th1 T helper subpopulations of T cells but not of Th2 helper cells. This activity is antagonized by IL-4. The inhibitory effect on IFN- gamma production is indirect and appears to be the result of a suppression of IL-12 synthesis by accessory cells. In the human system, IL10 is produced by, and down-regulates the function of, Th1 |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P18893 |
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| Catalog # | 500100 |
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| Order / More Info | IL10, Recombinant, Mouse (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF, Interleukin-10) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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