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| Product Name | IL10, Recombinant, Mouse (IL-10, Cytokine synthesis inhibitory factor, CSIF, Interleukin-10) |
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| Description | Purity ~95% (SDS-PAGE). IL-10 is produced by mouse Th2-cells following their stimulation by lectins. The main source for B-cell derived IL-10 in mice are Ly1 B-cells that express CD5 (Ly1) and CD11. In humans IL-10 is produced by activated CD8(+) peripheral blood T-cells, by T-helper CD4(+) T cell clones after both antigen-specific and polyclonal activation, by B cell lymphomas, and by monocytes following cell activation by bacterial lipopolysaccharides and mast cells. IL-10 is a homodimeric protein with subunits having a length of 160aa. Human Interleukin10 shows 73% amino acid homology with mouse Interleukin-10. The murine IL-10 receptor has been cloned. This receptor is a protein of approximately 110kD that binds murine IL-10 specifically. This receptor is structurally related to receptors for IFN. The CD nomenclature for this receptor is CDw210. IL-10 inhibits the synthesis of a number of cytokines such as IFN-gamma, IL-2 and TNF-beta in Th1 T-helper subpopulations of T-cells but not of Th2 T-helper cells |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P18893 |
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| Catalog # | 500101 |
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| Order / More Info | IL10, Recombinant, Mouse (IL-10, Cytokine synthesis inhibitory factor, CSIF, Interleukin-10) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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