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| Product Name | IL33, Recombinant, Mouse (IL-33, Interleukin-33) |
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| Description | Purity ~95% (SDS-PAGE). IL-33, a member of the IL-1 family, signals via a heterodimeric receptor complex consisting of ST2 and IL-1R accessory protein and triggers the activation of NF-B and all three MAPKs: p38, ERK1/2, and JNK1/2 in mast cells. IL-33 is expressed in multiple tissues and by several cell types such as dermal fibroblasts and small airway epithelial and bronchial smooth muscle cells. IL-33 activated IL-1-like signaling responses in mast cells and enhanced IL-5 and IL-13 production from murine Th2-polarized splenocytes. Moreover, it was found that both human and murine mast cells when stimulated in vitro with IL-33 produced a wide spectrum of cytokines and chemokines. In addition, IL-33 enhanced IL-4-driven Th2 cell responses and acted as a selective chemoattractant for Th2 cell recruitment. Source: Recombinant protein corresponding to mouse IL33 expressed in E. coli. Molecular Weight: ~18kD Biological Activity: The ED50 was determined by the dose-dependent proliferation of murine D10S cells is |
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| Size | 10ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q8BVZ5 |
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| Catalog # | 500156 |
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| Order / More Info | IL33, Recombinant, Mouse (IL-33, Interleukin-33) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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