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| Product Name | Dectin-1, Recombinant, Mouse |
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| Description | Purity ≥ 95%, as determined by SDS-PAGE and visualized by silver stain. Dectin-1, also known as CLEC7A and the β-glucan receptor, is a 43kD type II transmembrane C-type lectin that functions in the innate immune response to fungal pathogens. Although Dectin-1 resembles other CLEC molecules structurally, it binds ligands in a calcium-independent manner (1, 2). Mature mouse Dectin-1 is a 244 aa glycoprotein that consists of a short ITAM-containing cytoplasmic tail, a transmembrane segment, and a stalk and carbohydrate recognition domain (CRD) in the extracellular domain (3). The CRD of mouse Dectin-1 shares 61%, 60%, and 87% aa sequence identity with that of bovine, human, and rat Dectin-1, respectively. It shares 25%-34% aa sequence identity with the CRD of other subgroup members CLEC-1, CLEC-2, CLEC9A, CLEC12B, LOX-1, and MICL. Mouse Dectin-1 is alternately spliced, generating a variant that lacks the stalk region (4). Mouse Dectin-1 is expressed on monocytes, macrophages, and neu |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Dectin-1, Recombinant, Mouse (C-type lectin domain family 7 member A, Dendritic cell-associated C-type lectin 1, DC-associated C-type lectin 1, Beta-glucan receptor, C-type lectin superfamily member 12, CLEC7A, BGR, CLECSF12, DECTIN1, UNQ539/PRO1082) |
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| Gene, Accession, CAS # | SwissProt: Q6QLQ4 |
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| Catalog # | D1876-48B |
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| Order / More Info | Dectin-1, Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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