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| Product Name | Kijanimicin (Antibiotic Sch 25663) |
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| Description | Purity ~99% by HPLC. Kijanimicin is a tetronic acid related to saccharocarcin, chlorothricin, versipelostatin and tetrocarcin. Like the tetrocarcins, kijanimicin contains an unusual nitro-aminoglycoside. Kijanimicin is a potent antibacterial, antimalarial and antitumor activity. However, several members of this class have received considerable literature focus. Versipelostatin was shown to inhibit transcription from the promoter of GRP78, a gene that is activated as part of a stress signaling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells. While tetrocarcin A appears to target the phosphatidylinositide-3'-kinase/Akt signaling pathway. Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility |
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| Size | 500ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Antibiotic Sch 25663 |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | K1765-30 |
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| Order / More Info | Kijanimicin (Antibiotic Sch 25663) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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