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| Product Name | Kpnb1, Recombinant, Mouse, aa1-876, His-Tag (Importin Subunit beta-1) |
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| Description | Purity ~90% (SDS-PAGE). Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal prote |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Karyopherin subunit beta-1, Nuclear factor p97, Pore targeting complex 97kD subunit, PTAC97SCG |
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| Gene, Accession, CAS # | SwissProt: P70168 |
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| Catalog # | 373949 |
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| Order / More Info | Kpnb1, Recombinant, Mouse, aa1-876, His-Tag (Importin Subunit beta-1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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