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| Product Name | Kremen2, Recombinant, Rat |
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| Description | Purity ≥ 85%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain.Endotoxin: ≤ 1EU/1ug. Kremen (Kringle-containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains, and an intracellular region with no conserved motifs (1). Two related molecules, Kremen-1 and -2, have been identified. Kremens bind with high affinity to a subset of the secreted Dickkopf proteins (Dkk-1, -2, and -4) to modulate the canonical Wnt signaling pathway (2). This pathway is transduced by a ternary receptor complex composed of Wnt, the seven-transmembrane domain receptor Frizzled, and the LDL-receptor-related protein 5/6 (LRP5/6) coreceptor (3, 4). Dkk-1 and -4 bind directly to the LRP5/6 coreceptor to antagonize the canonical Wnt/b-catenin signaling pathway. The planar cell polarity (PCP) signaling pathway is not affected as it does not involve LRP5/6 (2). In contrast, Dkk-3 has no effect on Wn |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Kremen2, Recombinant, Rat (Kringle-containing Protein Marking the Eye and the Nose, Kringle Domain-containing Transmembrane Protein 2) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | K5002-02 |
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| Order / More Info | Kremen2, Recombinant, Rat from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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