| 产品详情 |
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| Product Name | ATR Kinase Inhibitor II |
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| Description | Purity ~97% (HPLC). A cell-permeable aminopyrazinyl-sulfone compound that acts as a potent, reversible and ATP-competitive inhibitor of ATR kinase (IC50 = 12nM; Ki = 6nM) with excellent selectivity over ATM, DNA-PK (IC50 > 8uM) and in a 50-kinase panel (% inhibition at 2uM = 59, 57, 55, 52, 43 and 42 for AMPK, Lck, RIPK2, Ret, IKK-alpha and FGFR3, respectively). Shown to block pH2AX-Ser139 (IC50 = 420nM in hydroxyurea treated HT29 cells) and preferentially enhance cisplatin cytotoxicity against tumor cells over normal cells by ~7-fold at 620nM. Formula: C22H25N5O3S Solubility: DMSO |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ATR Kinase Inhibitor II (3-Amino-6-(4-((1-(dimethylamino)propan-2-yl)sulfonyl)-phenyl)-N-phenylpyrazine-2-carboxamide) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217201 |
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| Price | |
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| Order / More Info | ATR Kinase Inhibitor II from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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| 产品资料 |
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