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| Product Name | Mucin 16, Recombinant, Human |
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| Description | Purity ≥90% as determined by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin: ≤1EU/ug protein (LAL). MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. Expression of isoforms, proteolytic cleavage, and heavy N- and O- linked glycosylation produce forms of human MUC16 that can vary from 1148-22152aa in length and 200-5000kD in size. The 22152aa form contains ser/thr-rich N-terminal tandem repeats, 4 LRR (Leu-rich repeat) domains, 56 SEA (sea urchin sperm protein, enterokinase and agrin) domains, a transmembrane domain, and a 31aa cytoplasmic domain that includes a tyrosine phosphorylation site. SEA domains are ~120aa in length, contain conserved residues including potential O-glycosylation sites and a pair of cysteines, and are of ten found in transmembrane mucins. The protein represents aa21102-21992 of the full sequen |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Mucin 16, Recombinant, Human (MUC16, MUC-16, CA125, CA-125, CA125 Ovarian Cancer Antigen, Cancer Antigen 125, FLJ14303, Mucin 16 Cell Surface Associated, Ovarian Cancer Antigen, Ovarian Cancer-related Tumor Marker CA125, Ovarian Carcinoma Antigen CA125) |
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| Gene, Accession, CAS # | SwissProt: Q8WXI7 |
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| Catalog # | M4701-94 |
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| Order / More Info | Mucin 16, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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