| 产品详情 |
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| Product Name | Fbxo3 Inhibitor, BC-1215 |
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| Description | Purity ~98% (HPLC). A cell-permeable, bis-pyridinylbenzylethanamine that disrupts Fbxo3-Fbxl2 interaction and effectively prevents SCF-Fbxo3-catalyzed Fbxl2 ubiquitination, resulting in cellular Fbxl2 upregulation and thereby SCF-Fbxl2-catalyzed TRAFs (TNF Receptor-Associated Factors) ubiquitination. Effectively reduces cellular TRAFs (5 to 127uM) and prevents TRAF-mediated cytokines production from LPS-stimulated human PBMC (25uM). Shown to greatly prevent Cecal Ligation & Puncture-induced plasma cytokine elevation and substantially reduce the severity of lung inflammation post intratracheal P. aeruginosa infection in mice (100ug/mouse; i.p.) in vivo. Primary Target: Fbox3 Solubility: DMSO |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Fbxo3 Inhibitor, BC-1215 (N1,N2-bis(4-(Pyridin-2-yl)benzyl)ethane-1,2-diamine, F Box Only Protein 3 Inhibitor, F Box Protein 3 Inhibitor, BC1215, F Box and Leucine-rich Repeat Protein 2 Activator, Fbxl2 Activator) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217355 |
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| Order / More Info | Fbxo3 Inhibitor, BC-1215 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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