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| Product Name | Purvalanol A, Free Base, 99+% |
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| Description | Purity ≥99% (HPLC, TLC). Purvalanol A is a cell-permeable, potent, and selective cyclin-dependent kinase (CDK) inhibitor. It inhibited CDK kinases with IC50 values of 4 nM for CDC2/cyclin B, 70 nM for CDK2/cyclin A, 35 nM for CDK2/cyclin E, 75 nM for CDK5/p35, and 850 nM for CDK4/cyclin D1. Gray N.S., et al. ``Exploiting chemical libraries, structure and genomics in the search for kinase inhibitors.'' Science 281: 533-538 (1998). Purvalanol A inhibited radiation-induced CDC2 kinase activity and induced apoptosis by increasing the levels of active fragments of caspase 3. Lizuka D., et al. ``Purvalanol A enhances cell killing by inhibiting up-regulation of CDC2 kinase activity in tumor cells irradiated with high doses of X rays.'' Radiat. Res. 167: 563-571 (2007). Purvalanol A prevented hippocampal proliferation in a time- and concentration -dependent manner. Mackowiak M., et al. ``Purvalanol A, inhibitor of cyclin-dependent kinases attenuates proliferation of cells in the dentate gyrus of the adult rat hippocampus.'' |
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| Size | 25mg, 50mg, 100mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 368499 |
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| Order / More Info | Purvalanol A, Free Base, 99+% from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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