| 产品详情 |
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| Product Name | PX-866 |
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| Description | Purity ~99%. PX-866, a derivative of wortmannin, potently inhibited purified phosphoinositide (PtdIns)-3-kinase (IC50=0.1nM) and PtdIns-3-kinase signaling (IC50=20nM) as assessed by phospho-Ser473-Akt levels in HT-29 colon cancer cells. PX-866 showed antitumor activity in vivo against s.c. A-549 human lung cancer xenografts and OvCar-3 human ovarian cancer in immunodeficient mice. PX-866 also enhanced the antitumor activity of cisplatin against A-549 xenografts and radiation treatment against OvCar-3 xenografts. Solubility: Soluble in DMSO at 200mg/ml; soluble in ethanol at 200mg/ml; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20uM; buffers, serum, or other additives may increase or decrease the aqueous solubility. |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PX-866 ([(3aR,6E,9S,9aR,10R,11aS)-6-[[bis(prop-2-enyl)amino]methylidene]-5-hydroxy-9-(methoxymethyl)-9a,11a-dimethyl-1,4,7-trioxo-2,3,3a,9,10,11-hexahydroindeno[4,5-h]isochromen-10-yl] acetate, DJM-166, DJM-2-166) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | P9394-50 |
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| Order / More Info | PX-866 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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