| 产品详情 |
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| Product Name | P2X Antagonist III |
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| Description | Purity ~98% (HPLC). A phenylthio-nicotinamide that acts as a high affinity P2X7 antagonist (pKi = 8.7 and 7.9, respectively, against 30nM A-804598 for rat and human P2X7 binding) and potently inhibits P2X7-dependent cellular Ca2+ mobilization (pIC50 = 8.3, 7.5, and 7.2, respectively, using 1321N1 expressing human, mouse, or rat P2X7; drug added 0.5 h prior to 3 min 0.25 mM BzATP stimulation), while exhibiting much reduced or little potency toward a panel of 50 ion channels, transporters, and receptors. Although not suitable for oral dosing due to high hepatic extraction ratios, effective delivery and brain P2X7 occupancy can be achieved via s.c. dosing in rats (30mg/kg) in vivo. Formula: C28H32N4O2S Primary Target: P2X7 Solubility: DMSO (100mg/ml) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | P2X Antagonist III (Purinergic Receptor P2X Antagonist III, N-((4-(4-Phenylpiperazin-1-yl)tetrahydro-2H-pyran-4-yl)methyl)-2-(phenylthio)nicotinamide) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217614 |
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| Order / More Info | P2X Antagonist III from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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