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| Product Name | Lipoprotein Receptor, Very Low Density, Recombinant, Mouse (VLDLR) |
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| Description | Purity ≥ 85%, as determined by SDS-PAGE and visualized by silver stain. VLDL R is a 105 kD type I integral membrane protein that belongs to the LDL receptor family. It plays a significant role in lipid metabolism and in nervous system development and function. 1,2 Mouse VLDL R has a 770 amino acid (aa) extracellular domain (ECD) and a 54 aa cytoplasmic region. The ECD contains eight LDLR class A repeats, three EGF-like repeats, six LDLR class B repeats, and a juxtamembrane region that is rich in O-linked glycosylation. 3,4 The cytoplasmic domain contains one NPXY internalization motif. VLDL R is predominantly expressed in striated muscle, adipose tissue, brain, and endothelial cells lining capillaries and small arterioles. 3-6 VLDL R participates in the tissue uptake of fatty acids from plasma by mediating the internalization of ApoE-containing lipoparticles (i.e. VLDL, β-VLDL, and chylomicron remnants). 5,7 VLDL R binds and internalizes lipoprotein lipase (LPL) and mediates its t |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: AAA59384 |
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| Catalog # | L2601-35 |
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| Order / More Info | Lipoprotein Receptor, Very Low Density, Recombinant, Mouse (VLDLR) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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