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| Product Name | Mst1, Recombinant, Mouse |
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| Description | Purity ~95% (reducing SDS-PAGE) Endotoxin: ~1EU/1ug (LAL). Macrophage stimulating protein (MSP), also known as HGF-like protein, and scatter factor-2, is a member of the HGF family of growth factors. MSP is secreted as an inactive single chain precursor (pro-MSP) that contains a PAN/APPLE-like domain, four kringle domains, and a peptidase S1 domain which lacks enzymatic activity. Mouse MSP shares 79% and 93% aa sequence identity with human and rat MSP, respectively and 42% aa sequence identity with mouse HGF. Pro-MSP is secreted by hepatocytes under the positive and negative control of CBP in complex with either HNF-4 or RAR, respectively. Circulating pro-MSP is proteolytically cleaved in response to tissue injury to yield biologically active disulfide linked heterodimers consisting of a 45-62kD alpha and a 25-35kD beta chain. Pro-MSP can be activated by MT-SP1, a transmembrane protease that is expressed on macrophages and is upregulated in many cancers. Heterodimeric MSP, as well as t |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Mst1, Recombinant, Mouse (Hepatocyte Growth Factor-like Protein, Macrophage Stimulatory Protein, MSP, Hgfl) |
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| Gene, Accession, CAS # | Accession: NP_032269 |
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| Catalog # | M1203-96 |
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| Order / More Info | Mst1, Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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