| 产品详情 |
| Edit |   |
|---|
| Product Name | Transforming Growth Factor-alpha, Recombinant, Human |
|---|
| Description | Purity ~98% (SDS-PAGE, HPLC). Transforming growth factors (TGFs) are biologically active polypeptides that reversibly confer the transformed phenotype on cultured cells. TGF-alpha shows about 40% sequence homology with epidermal growth factor including 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds. TGF-alpha competes with EGF for binding to the EGF receptor, stimulating its phosphorylation and producing a mitogenic response. Human TGF-alpha or Sacroma growth factor, TGF-type I, ETGF (precursor 160aa, mature form 50aa, aa40-89; chromosome 2p13) Interacts with the PDZ domains of SDCBP and SNTA1 and Contains 1 EGF-like domain. The interaction with SDCBP, is required for the targeting to the cell surface. TGF-alpha is synthesized and secrted by monocytes, keratinocytes and many normal and tumor cells and tissues. Mice genetically engineered to be lacking TGF-alpha expression showed no abnormalities except for the detection of a wavy hair coat. Source: Recombi |
|---|
| Size | 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | Transforming Growth Factor-alpha, Recombinant, Human (TGF-alpha, Sacroma Growth Factor, TGF-type I, ETGF) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 209255 |
|---|
| Price | |
|---|
| Order / More Info | Transforming Growth Factor-alpha, Recombinant, Human from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|