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| Product Name | ROS1, Recombinant, Arabidopsis thaliana, aa1-320, His-SUMO-Tag (Protein ROS1) |
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| Description | Purity ~90% (SDS-PAGE). Bifunctional DNA glycosylase/lyase, which excises 5-methylcytosine (5-meC) and 5-hydroxymethylcytosine (5-hmeC), leaving an apyrimidinic (AP) site that is subsequently incised by the lyase activity (PubMed:25240767). Generates 3'-phosphor-alpha,beta-unsaturated aldehyde (3'-PUA) as a primary 5-meC excision intermediate (PubMed:25228464). Prevents DNA hypermethylation, specifically in the promoter of otherwise silenced loci. May be involved in DNA repair through its nicking activity on methylated DNA. Binds with similar affinity to both methylated and non-methylated DNA. Highly distributive behavior on DNA substrates containing multiple 5-meC residues. Involved with Pol IV in the remodeling of the 5S rDNA chromatin via DNA methylation modifications during the first days of development post-germination. Participates in UV-B induced- and oxidative DNA damage repair (PubMed:24155752). Source: Recombinant protein corresponding to aa1-320 from arabidopsis thaliana ROS1, fused to His-SUMO-Tag |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | DEMETER-like protein 1 Repressor of silencing 1 |
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| Gene, Accession, CAS # | SwissProt: Q9SJQ6 |
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| Catalog # | 375084 |
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| Order / More Info | ROS1, Recombinant, Arabidopsis thaliana, aa1-320, His-SUMO-Tag (Protein ROS1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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