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| Product Name | BACE, Asp2 Beta-Secretase Peptide Substrate, Human |
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| Description | Highly purified. A 14 aa peptide corresponding to the known b-secretase site of human APP590-603 were synthesized and purified by HPLC. beta-amyloid (Abeta) deposition in the brain is the hallmark of Alzheimer's Disease (AD). To initiate Ab formation, beta-secretase cleaves APP at the N-terminus of Ab to release APPsb (~100kD soluble NT-fragment), and C99, a 12-kD CT membrane fragment. Alternatively, alpha-secretase cleaves within the Ab to prevent the formation of Ab. Cleavage by a-secretase produces a soluble N-terminal fragment, APPsa, and a 10-kD membrane C-terminal fragment, C83. Both C99 and C83 can be further cleaved by gamma-secretase releasing Ab and a nonpathogenic p3 peptide, respectively. Recently, BACE (Beta-site APP Cleaving Enzyme) has been identified as b-secretase. BACE belongs to the family of Aspartyl proteases (Asp) also known as Memapsins. At least four related Asps, located on chromosome IV and X, have been cloned (Asp1, Asp2, Asp3, and Asp4). Human BACE/Asp2/Mema |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | BACE, Asp2 Beta-Secretase Peptide Substrate, Human (Memapsin2, Beta-site APP Cleaving Enzyme, Aspartyl Protease 2) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | B0002-90A |
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| Order / More Info | BACE, Asp2 Beta-Secretase Peptide Substrate, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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