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| Product Name | BACE, Asp2, CT, Blocking Peptide (Beta-site APP Cleaving Enzyme, Aspartyl Protease 2) |
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| Description | Purified 60-70%. Peptide corresponding to amino acids 485 to 501 of human BACE (1). Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor (APP) at b-and g-sites by two proteases. APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4kD amyloid-b peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP. |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | B0002-90P |
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| Order / More Info | BACE, Asp2, CT, Blocking Peptide (Beta-site APP Cleaving Enzyme, Aspartyl Protease 2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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