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| Product Name | BACE2, Asp1, NT, Blocking Peptide |
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| Description | Purified 60-70%. Peptide (APTPGPGTPAERHADG) corresponding to amino acids 44 to 59 of human BACE2 (4). Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor (APP) at b-and g-sites by proteases. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4-9). BACE2 also cleaves APP at b-site and at a different site within Ab (8). BACE2 locates on chromosome 21q22.3, the so-called `Down critical region', suggesting that BACE2 and Ab may also contribute to the pathogenesis of Down syndrome (6,7) Applications: Suitable for use in ELISA, Western Blotting. Positive Control: Human heart tissue lysate can be |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | BACE2, Asp1, NT, Blocking Peptide (Beta-site APP Cleaving Enzyme, Aspartyl Protease 2, DRAP, Down Region Aspartic Protease, Memapsin) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | B0003P |
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| Order / More Info | BACE2, Asp1, NT, Blocking Peptide from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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