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| Product Name | COT, Recombinant, Human, GST-tag |
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| Description | Purified (~70-90%). COT is an oncogene that can activate both the MAP kinase and JNK kinase pathways. COT activates IkappaB kinases and induces the nuclear production of NF-kappaB. C-terminal catalytic domain of KSR2 associates with COT and KSR2 can negatively regulates the kinase activity of COT in vitro. Co-transfection of KSR2 with COT in cells lead to reduced COT-mediated ERK activation and COT-induced IL8 production in a dose-dependent manner. Cot is one of the MAP kinase kinase kinases that regulates the ERK1/ERK2 pathway in response to IL-1. Blockage of expression of Cot results in failure of IL-1 to induce an increase in IL-8 and MIP-1betamRNA levels. Source: Recombinant protein corresponding to human COT fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~70kD Specific Activity: 1012nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | COT, Recombinant, Human, GST-Tag (Cancer Osaka Thyroid Oncogene, Mitogen-activated Protein Kinase Kinase Kinase 8, MAP3K8, EST, ESTF, TPL2, Tpl-2, c-COT, FLJ10486) |
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| Gene, Accession, CAS # | Accession: NM_005204 |
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| Catalog # | 499900 |
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| Order / More Info | COT, Recombinant, Human, GST-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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